All measurements at a holding voltage Vh=−70 mV and chloride reversal potential ECl=−21 mV. The age of the R6/2 cohort was 78.0 ± 1.1 days, n= 91 vs. CAR 75.0 ± 1.2 days, n= 77 (n.s.). Abbreviations: n, number of neurons; p value, significance level; for all other abbreviations see list on Introduction page.
Article: Tonic mGluR5/CB1-dependent suppression of inhibition as a pathophysiological hallmark in the striatum of mice carrying a mutant form of huntingtin.
Full Text (publisher's website) ; Article Metadata ; Article Data (extracted) Dvorzhak A; Semtner M; Faber DS; Grantyn R J. Physiol. (Lond.), 2013
Property | WT | CAR | p value | Test | ||||
---|---|---|---|---|---|---|---|---|
Mean | ±SEM | n | Mean | ±SEM | n | |||
Membrane potential (mV) | −69.5 | 0.58 | 108 | −60.5 | 0.96 | 101 | <0.0001 | Mann-Whitney’s U test |
Whole-cell input resistance (MΩ) | ||||||||
Intracellular standard | 59.2 | 2.50 | 107 | 128.2 | 8.44 | 99 | <0.0001 | Mann-Whitney’s U test |
Intracellular with GDPβS | 38.1 | 3.10 | 13 | 72.70 | 4.80 | 37 | <0.0010 | Student's unpaired t test |
Whole-cell capacitance (pF) | 79.7 | 1.91 | 107 | 66.1 | 1.63 | 99 | <0.0001 | Student's unpaired t test |
Reobasic current (pA) | 189.6 | 11.66 | 71 | 97.3 | 6.14 | 66 | <0.0001 | Mann-Whitney’s U test |
Inferred neuron-electrophysiology data values
Neuron Type | Neuron Description | Ephys Prop | Extracted Value | Standardized Value | Content Source |
---|---|---|---|---|---|
Neostriatum medium spiny neuron | input resistance | 59.2 | 59.2 (MΩ) | Data Table | |
Neostriatum medium spiny neuron | resting membrane potential (mV) | -69.5 | -69.5 (mV) | Data Table | |
Neostriatum medium spiny neuron | cell capacitance (pF) | 79.7 | 79.7 (pF) | Data Table | |
Neostriatum medium spiny neuron | rheobase (pA) | 189.6 | 189.6 (pA) | Data Table |